By train
A very comfortable train ride links the city to Tel Aviv, Haifa, Netanya and Naharia with hourly departures.
By bus
From Tel Aviv: Take line 380 from Arlozorov Terminal, or line 370 from Tel Aviv Central Bus Station. The trip costs only 16.5 NIS. Both take about 1.5 hours.
From Jerusalem: From central bus station - line 470, 30 NIS, one and a half hours; line 446, 30 NIS, 1 hour and 50 minutes.
By plane
The closest airport is Ben Gurion, located outside Tel Aviv.
By road
From Tel Aviv: Use Highway 20 Ayalon to connect to Highway 4 towards Ashdod, then turn to Highway 41 in order to connect to Highway 40 south. Straight to Be'er Sheva approximately 1 1/2 hrs.
From Jerusalem: Highway 1 towards Tel Aviv, Pick up route 3 at Latrun interchange, follow for 20 minutes to Route 40 at Re'em Junction. Straight ahead to Be'er Sheva. Total about 1:40.